Order KPV Peptide For Sale In USA – KPV Peptide (Lys-Pro-Val) – High Purity ≥99% | cGMP Grade for Anti-Inflammatory & Immune Research

KPV Peptide (Lys-Pro-Val) is a synthetic tripeptide (3 amino acids) corresponding to the C-terminal fragment (amino acids 11-13) of alpha-melanocyte-stimulating hormone (α-MSH). Despite its small size, KPV retains the potent anti-inflammatory and immunomodulatory properties of the full-length α-MSH molecule.

KPV functions primarily by inhibiting the nuclear factor kappa-B (NF-κB) signaling pathway, a master regulator of inflammation. It reduces the production of pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, and IL-8 while increasing the anti-inflammatory cytokine IL-10. Unlike α-MSH, KPV lacks melanotropic activity (no melanin production), making it a focused research tool for inflammation studies.

Research demonstrates KPV’s efficacy in inflammatory bowel disease (IBD) models, dermatitis, uveitis, arthritis, and other inflammatory conditions. Its small size, stability, and selective anti-inflammatory mechanism make it valuable for topical and systemic inflammation research.

At Shanghai AmbioPharm, Inc., we supply high-purity KPV Peptide (≥99% by HPLC) for advanced inflammation and immune research. Our cGMP-grade material is synthesized in our FDA-inspected Shanghai facility and available for fast U.S. delivery from our Clearwater, South Carolina warehouse.

Key Product Details:

• Sequence: Lys-Pro-Val (KPV)

• Full Name: Lysyl-Prolyl-Valine

• Origin: α-MSH fragment (11-13)

• CAS Number: 946870-92-4 (KPV acetate)

• Molecular Formula: C₁₆H₃₁N₅O₄

• Molecular Weight: 357.45 g/mol (free base), approximately 417.5 g/mol (acetate salt)

• Purity: ≥99% (HPLC)

• Form: Lyophilized white powder

• Storage: -20°C, protected from light, desiccated

• Grade Available: Non-GMP (R&D) and cGMP (clinical preparatory)

• Amino Acids: 3-mer (tripeptide)

• Key Property: Anti-inflammatory, no melanotropic activity

• Primary Target: NF-κB signaling pathway

Premium KPV Peptide for Sale – High Purity Research Grade

Looking for KPV peptide for sale from a trusted supplier? Shanghai AmbioPharm, Inc. offers high purity KPV peptide manufactured under advanced, quality-controlled environments to support modern research applications. KPV (Lysine–Proline–Valine) is a short-chain peptide widely studied in biochemical and peptide research, making it a valuable compound for scientific and laboratory use.

Our KPV peptide is synthesized using pharmaceutical-grade processes to ensure ≥99% purity, excellent stability, and consistent batch performance. Each batch undergoes strict quality verification and includes a Certificate of Analysis (COA), ensuring full transparency and reliability. Designed to meet the needs of professional research environments, our peptide delivers consistent and dependable performance.

With our manufacturing facility in Shanghai and USA-based distribution support, we ensure fast, secure shipping and reliable supply for both small-scale and bulk orders. Whether for laboratory studies or bulk procurement, we provide flexible solutions tailored to your research needs.

Why Choose AmbioPharm for KPV Peptide?

As a global peptide CDMO, AmbioPharm combines scientific expertise with large-scale manufacturing capabilities. Choosing our KPV peptide for sale ensures premium quality, trusted sourcing, and reliable delivery tailored to your research needs.

• ✅ FDA-inspected cGMP manufacturing

• ✅ Full Certificate of Analysis (COA) with each batch

• ✅ HPLC chromatogram and mass spec data included

• ✅ Verified NF-κB inhibition activity confirmation

• ✅ Low endotoxin levels (<1 EU/mg)

• ✅ U.S. warehousing – fast domestic shipping from South Carolina

• ✅ Batch-to-batch consistency for inflammation studies

Research Applications:

• NF-κB pathway inhibition and inflammation research

• Inflammatory bowel disease (IBD) and colitis models

• Dermatitis, psoriasis, and skin inflammation research

• Uveitis and ocular inflammation studies

• Arthritis and joint inflammation models

• Cytokine modulation (TNF-α, IL-1β, IL-6, IL-10) research

• Sepsis and systemic inflammation models

• Wound healing and anti-scarring research

Mechanism of Action:
KPV binds to melanocortin receptors (likely MC1R) on immune cells, initiating downstream signaling that inhibits IκB kinase (IKK) complex activation. This prevents IκBα phosphorylation and degradation, retaining NF-κB in the cytoplasm bound to IκBα. Nuclear translocation of NF-κB p65 subunit is blocked, reducing transcription of pro-inflammatory genes. KPV also suppresses MAPK pathway activation (p38, JNK, ERK), further dampening inflammatory responses without melanogenic effects.

 Intended Use: For laboratory research purposes only. Not for human consumption or clinical use without regulatory approval.

Ordering Information:

• Minimum Order Quantity (MOQ): 5mg (R&D), 10g+ (cGMP bulk)

• Lead Time: 2-3 weeks (non-GMP), 6-8 weeks (cGMP)

• Shipping: From Clearwater, SC, USA (2-5 days domestic)